-synuclein, which can be a primary element of Lewy bodies, in PARK one in 1997 and parkin in PARK two in 1998, and that is an E3 ubiquitin ligase and causes endoplasmic reticulum (ER) tension, counsel that dysfunction of the intracellular proteinase programs, for example ubiquitin-proteasome technique or lysosomal system, which gets rid of pointles